Journal article
Cisplatin-Induced Formation of Biocompatible and Biodegradable Polypeptide-Based Vesicles for Targeted Anticancer Drug Delivery
SJ Shirbin, K Ladewig, Q Fu, M Klimak, X Zhang, W Duan, GG Qiao
Biomacromolecules | Published : 2015
Abstract
Novel cisplatin (CDDP)-loaded, polypeptide-based vesicles for the targeted delivery of cisplatin to cancer cells have been prepared. These vesicles were formed from biocompatible and biodegradable maleimide-poly(ethylene oxide)114-b-poly(L-glutamic acid)12 (Mal-PEG114-b-PLG12) block copolymers upon conjugation with the drug itself. CDDP conjugation forms a short, rigid, cross-linked, drug-loaded, hydrophobic block in the copolymer, and subsequently induces self-assembly into hollow vesicle structures with average hydrodynamic diameters (Dh) of ∼270 nm. CDDP conjugation is critical to the formation of the vesicles. The reactive maleimide-PEG moieties that form the corona and inner layer of th..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
S.J.S would like to thank The University of Melbourne, the Commonwealth Scientific and Industrial Research Organisation (CSIRO), and the Melbourne Materials Institute (MMI) for various scholarships. The authors would like to acknowledge the Australian Research Council (ARC) for funding in the form of a Discovery Project (DP140100002). Q.F and K.L. acknowledges financial support from the ARC in the form of an ARC Super Science Fellowship (FS 110200025). G.G.Q acknowledges the ARC under the Future Fellowship (FT110100411, G.G.Q.) The authors would also like to thank Ms. Lynne Waddington (CSIRO) for help with TEM and Ms. E Nam for help with AFM analysis.